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| Office-based thermal-treatments for unmet urological diseases in women and men |
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Elmedical looks for distributors world wide
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BWT (Bladder Wall Thermochemotherapy) / UniThermia:
BWT treats non-muscle invasive bladder cancer (NMIBC).
BWT provides bladder wall thermochemotherapy with uniform hyperthermia (UniThermia) all over the bladder by high flow of a heated mitomycin C solution.
BWT based on conductive-heat which is better controlled in the bladder than microwave. In BWT, heat administered precisely and uniformly all over the bladder without burns ("hot spots”) or ineffective low heating ("cold spots”).
BWT for NMIBC performed in two protocols:
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Prophylaxis protocol: a 50 minutes procedure with uniform 44.50C on bladder wall, in which 40mg MMC dissolved in 50ml distilled water. |
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Ablation protocol: a 50 minutes procedure with uniform 44.50C on bladder wall, in which 80mg MMC dissolved in 50ml distilled water. |
BWT inherent features:
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The better controlled conductive heat leads to better drug stability. |
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The high rate circulation in the bladder continuously brings "fresh" heated drug in contact with all bladder wall. |
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Uniform and precise bladder wall temperature maintained all over the bladder while there are:
- No "hot spots" (burns in posterior bladder wall), and
- No "cold spots" (ineffective low heating near the bladder dome or trigone). |
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The uniform and precise temperature enables increase of the targeted temperature to 44.50C without adverse events. |
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The absence of burns leads to increased patient tolerability to the treatment. |
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Non-traumatic insertion of the 18Fr flexible catheter which has no rigid parts. |
Due to those inherent features, BWT by UniThermia in NMIBC expected to achieve, at least, the same efficacy as in microwave while excellent patients' tolerance and less adverse events already shown.
After more than 1,250 procedures performed, neither burns nor urethral strictures occurred.
Elmedical pursues to enhance the immediate post-TURBT single chemotherapy instillation (recommended in the EAU and AUA Guidelines) with BWT. The Company already performed successfully such post-TURBT immediate procedures in Israel, Italy and Spain.
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